Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
J Hum Hypertens. 2012 Dec;26(12):731-6. doi: 10.1038/jhh.2011.96. Epub 2011 Nov 3.
CYP17A1 gene encodes the cytochrome P450 enzyme CYP17A1, a key enzyme involved in steroid metabolism. A single nucleotide polymorphism (SNP) near CYP17A1, rs11191548, showed significant association with hypertension in European adults. However, this association has not been demonstrated in children thus far. Additionally, the role of CYP17A1 in elevating blood pressure (BP) is unclear. We investigated the association of rs11191548 with hypertension in Chinese children. A total of 3422 children participated in the study, including 1009 children with elevated BP (EBP, including prehypertension and hypertension) and 2413 children with normal BP. SNP rs11191548 was associated with systolic BP (SBP) (CC vs TT: P=4.8 × 10(-4); additive model: P=0.002; dominant model: P=0.011; recessive model: P=0.001) and EBP (CC vs TT: odds ratio (OR)=0.43, 95% confidence interval (CI) 0.26-0.72, P=0.001; additive model: OR=0.74, 95% CI 0.61-0.90, P=0.002; dominant model: OR=0.76, 95% CI 0.60-0.96, P=0.022; recessive model: recessive model: OR=0.46, 95% CI 0.28-0.77, P=0.003) in girls, but there was no statistically significant association between the SNP and diastolic BP in boys or girls. Our results also showed that rs11191548 was more significantly associated with SBP and EBP in obese girls than in girls of normal weight. Our study indicated that the SNP rs11191548, near CYP17A1, was associated with EBP in children. Moreover, we found a sex-specific effect of rs11191548 on SBP in Chinese children. Further studies are necessary to clarify the association between this CYP17A1 polymorphism and BP.
CYP17A1 基因编码细胞色素 P450 酶 CYP17A1，这是一种参与类固醇代谢的关键酶。CYP17A1 附近的单核苷酸多态性（SNP）rs11191548 与欧洲成年人的高血压显著相关。然而，到目前为止，这种关联在儿童中尚未得到证实。此外，CYP17A1 在升高血压（BP）方面的作用尚不清楚。我们研究了 rs11191548 与中国儿童高血压的关系。共有 3422 名儿童参与了这项研究，包括 1009 名高血压儿童（EBP，包括前期高血压和高血压）和 2413 名血压正常的儿童。SNP rs11191548 与收缩压（SBP）（CC 与 TT：P=4.8×10(-4)；加性模型：P=0.002；显性模型：P=0.011；隐性模型：P=0.001）和 EBP（CC 与 TT：比值比（OR）=0.43，95%置信区间（CI）0.26-0.72，P=0.001；加性模型：OR=0.74，95%CI 0.61-0.90，P=0.002；显性模型：OR=0.76，95%CI 0.60-0.96，P=0.022；隐性模型：隐性模型：OR=0.46，95%CI 0.28-0.77，P=0.003）有关，而在男孩或女孩中，该 SNP 与舒张压之间没有统计学显著关联。我们的结果还表明，在肥胖女孩中，SNP rs11191548 与 SBP 和 EBP 的关联比体重正常的女孩更为显著。我们的研究表明，CYP17A1 附近的 SNP rs11191548 与儿童的 EBP 有关。此外，我们发现 SNP rs11191548 在儿童的 SBP 中存在性别特异性作用。需要进一步的研究来阐明这种 CYP17A1 多态性与 BP 之间的关系。
