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变应性支气管肺曲霉菌病。一种在哮喘患者中日益常见的疾病。

Allergic bronchopulmonary aspergillosis. An increasingly common disorder among asthmatic patients.

作者信息

Richeson R B, Stander P E

机构信息

University of California, Davis, Medical Center, Sacramento.

出版信息

Postgrad Med. 1990 Sep 1;88(3):217-9, 222, 224. doi: 10.1080/00325481.1990.11704739.

DOI:10.1080/00325481.1990.11704739
PMID:2204899
Abstract

Allergic bronchopulmonary aspergillosis (ABPA), an immunologic disorder, is characterized by bronchial colonization with Aspergillus species, resulting in chronic antigenic stimulation. Hallmarks of the disorder are asthma, cutaneous and serologic evidence of hypersensitivity to Aspergillus organisms, and fleeting pulmonary infiltrates. Diagnosis requires a high index of suspicion. Early diagnosis, aggressive therapy, and serial monitoring of serum IgE levels usually prevent progression of ABPA to bronchiectasis, pulmonary fibrosis, respiratory failure, and death.

摘要

变应性支气管肺曲霉病(ABPA)是一种免疫紊乱疾病,其特征为支气管被曲霉菌种定植,导致慢性抗原刺激。该疾病的特点是哮喘、对曲霉菌生物体过敏的皮肤和血清学证据,以及短暂性肺部浸润。诊断需要高度的怀疑指数。早期诊断、积极治疗以及对血清IgE水平的连续监测通常可防止ABPA进展为支气管扩张、肺纤维化、呼吸衰竭和死亡。

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引用本文的文献

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Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus.烟曲霉诱导的变应性气道疾病期间的慢性气道高反应性、杯状细胞增生和支气管周围纤维化。
Am J Pathol. 2000 Feb;156(2):723-32. doi: 10.1016/S0002-9440(10)64775-X.