Montgomery Keith W, Ledbetter Eric C, Mohammed Hussni O
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Ophthalmol. 2011 Nov;14(6):395-9. doi: 10.1111/j.1463-5224.2011.00897.x. Epub 2011 Apr 26.
To perform a randomized, placebo-controlled, masked clinical trial using a cross-over design to determine the effect of oral diphenhydramine on aqueous tear production in normal dogs.
Seventeen dogs with normal ophthalmic examinations.
Baseline tear production was established for each dog by performing Schirmer tear test I (STT I). Dogs received 20-day treatment courses of both oral diphenhydramine and placebo solutions with a 10-day washout period between treatment periods. Each dog was randomly assigned to receive diphenhydramine or placebo at the outset of the study. Measurements of STT I values were measured at regular intervals during the study and were conducted at the same time of day throughout the study to control for diurnal variations in tear production. The significance of the impact of diphenhydramine treatment on the quantity of aqueous tear production, as determine by STT results over time, was evaluated using regression analysis with appropriate transformation.
Statistical comparisons at each measurement time, including baseline measurements between control and treatment groups, revealed no significant differences. Mean STT I levels also did not differ significantly at any measurement time compared to baseline for treatment or control groups.
Short-term administration of oral diphenhydramine does not result in a significant decrease in aqueous tear production in normal dogs.
采用交叉设计进行一项随机、安慰剂对照、双盲临床试验，以确定口服苯海拉明对正常犬泪液分泌的影响。
17只眼科检查正常的犬。
通过进行Schirmer泪液试验I（STT I）为每只犬建立基线泪液分泌量。犬接受口服苯海拉明和安慰剂溶液的20天治疗疗程，治疗期之间有10天的洗脱期。在研究开始时，每只犬被随机分配接受苯海拉明或安慰剂。在研究期间定期测量STT I值，并且在一天中的同一时间进行测量，以控制泪液分泌的昼夜变化。使用适当转换的回归分析评估苯海拉明治疗对泪液分泌量的影响的显著性，该影响由STT随时间的结果确定。
在每个测量时间点进行的统计比较，包括对照组和治疗组之间的基线测量，均未发现显著差异。与治疗组或对照组的基线相比，在任何测量时间点的平均STT I水平也没有显著差异。
短期口服苯海拉明不会导致正常犬泪液分泌量显著减少。
