Murphy J K, Edwards N B, Downs A D, Ackerman B J, Rosenthal T L
Department of Psychiatry, University of Tennessee, Memphis.
Am J Psychiatry. 1990 Oct;147(10):1353-7. doi: 10.1176/ajp.147.10.1353.
In a double-blind study, 15 cigarette smokers self-monitored 10 withdrawal symptoms. For the first 21 days (baseline), subjects received doxepin hydrochloride, up to 150 mg/day, or inert medication while continuing to smoke. On day 22, they were instructed to stop smoking; medication was continued. Withdrawal symptoms on the first 28 days of treatment (baseline and 7 days of attempted cessation) were analyzed. During cessation, subjects taking doxepin reported significantly less craving for cigarettes. Results from this study and others suggest that antidepressants may attenuate the severity of symptoms during withdrawal from addictive substances.
在一项双盲研究中，15名吸烟者自行监测10种戒断症状。在最初的21天（基线期），受试者服用盐酸多塞平，剂量高达150毫克/天，或服用惰性药物，同时继续吸烟。在第22天，他们被指示戒烟；继续服用药物。分析了治疗前28天（基线期和尝试戒烟的7天）的戒断症状。在戒烟期间，服用多塞平的受试者报告对香烟的渴望明显减少。这项研究和其他研究的结果表明，抗抑郁药可能会减轻成瘾物质戒断期间症状的严重程度。
