Ge Xi-Yuan, Yu Guang-Yan, Fu Jia, Wu Deng-Cheng, Zhang Xiao-Xia, Wang Yi-Xiang, Li Sheng-Lin
Department of Central Laboratory, Peking University School and Hospital of Stomatology, #22 Zhongguancun Nandajie, Haidian District, Beijing, China.
Br J Oral Maxillofac Surg. 2012 Sep;50(6):562-6. doi: 10.1016/j.bjoms.2011.10.004. Epub 2011 Nov 1.
We have evaluated transplantation of reduced submandibular glands for the treatment of severe keratoconjunctivitis sicca. Thirty-four rabbits were allocated into three groups: dry eye (controls, n=10), transplantation of whole submandibular glands (n=12), and transplantation of reduced submandibular glands (n=12). Outcome measures included the results of Schirmer's test and the Rose Bengal test, and histological examination of the cornea and the transplanted gland. Volume of tears significantly increased after transplantation of the whole gland, but did not change after transplantation of the reduced gland compared with dry eyes induced preoperatively. Neither transplantion group had keratoconjunctivitis sicca postoperatively. There were no histological abnormalities in the transplanted tissues. The results that the surgical technique of using reduced submandibular glands for transplantation was feasible, and that the secretion from the reduced gland was similar to that from a normal lacrimal gland. In conclusion, transplantation of a reduced submandibular glands is feasible in the treatment of keratoconjunctivitis sicca.
我们评估了移植缩小的下颌下腺治疗严重干眼症的效果。34只兔子被分为三组：干眼组（对照组，n = 10）、移植整个下颌下腺组（n = 12）和移植缩小的下颌下腺组（n = 12）。观察指标包括泪液分泌试验结果、孟加拉玫瑰红试验结果以及角膜和移植腺体的组织学检查。与术前诱导的干眼相比，移植整个腺体后泪液量显著增加，但移植缩小的腺体后泪液量未发生变化。两个移植组术后均无干眼症。移植组织无组织学异常。结果表明，使用缩小的下颌下腺进行移植的手术技术是可行的，且缩小腺体的分泌与正常泪腺相似。总之，移植缩小的下颌下腺治疗干眼症是可行的。
