Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ann Thorac Surg. 2011 Nov;92(5):1901-3. doi: 10.1016/j.athoracsur.2011.03.054. Epub 2011 Oct 31.
A 38-year-old woman with clinical T3N1M0 esophageal adenocarcinoma received an institutional protocol of induction chemotherapy, esophagectomy, and consolidation chemoradiotherapy. Three months after treatment, she had an acute mental status change develop and grand mal seizures. Intracranial imaging demonstrated massive cerebral air emboli, and a rapidly fatal neurologic deterioration ensued. At autopsy, a nonmalignant 0.5-cm gastric conduit to the left atrial fistula was identified. This case illustrates a rare, but fatal, late benign complication of aggressive therapy for locally advanced esophageal cancer.
一位 38 岁的女性患有临床 T3N1M0 食管腺癌，接受了机构诱导化疗、食管切除术和巩固放化疗方案。治疗后 3 个月，她出现急性精神状态改变和全身强直-阵挛性发作。颅内影像学显示大量脑空气栓塞，随后出现迅速致命的神经功能恶化。尸检发现，一个 0.5 厘米的非恶性胃导管通向左心房瘘。本病例说明了一种罕见但致命的晚期良性并发症，发生于局部晚期食管癌的积极治疗后。
