Thakuria Ranjit, Nangia Ashwini
School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
Acta Crystallogr C. 2011 Nov;67(Pt 11):o461-3. doi: 10.1107/S0108270111043952. Epub 2011 Oct 31.
2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine, C(17)H(20)N(4)S, commonly known as olanzapine, is a psychotropic agent that belongs to the thienobenzodiazepine class of drugs. A new polymorph form IV was obtained upon attempted cocrystallization with nicotinamide in a 1:1 ratio from an ethyl acetate solution. Two butterfly-like molecules form centrosymmetric dimers stabilized by weak C-H···π interactions between the 4-methylpiperazin-1-yl fragment and the benzene/thiophene aromatic system. Form IV consists of a herringbone arrangement of dimers, whereas the previously reported form II has parallel dimers. Both crystal structures are sustained by an N-H···N hydrogen bond.
2-甲基-4-(4-甲基哌嗪-1-基)-10H-噻吩并[2,3-b][1,5]苯二氮䓬，化学式为C(17)H(20)N(4)S，通常称为奥氮平，是一种精神药物，属于噻吩并苯二氮䓬类药物。尝试将其与烟酰胺以1:1的比例从乙酸乙酯溶液中共结晶时，得到了一种新的多晶型物IV。两个蝴蝶状分子形成中心对称二聚体，通过4-甲基哌嗪-1-基片段与苯/噻吩芳香体系之间的弱C-H···π相互作用得以稳定。晶型IV由二聚体的人字形排列组成，而先前报道的晶型II具有平行二聚体。两种晶体结构均由N-H···N氢键维持。
