Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Cell Death Differ. 2012 Jan;19(1):28-35. doi: 10.1038/cdd.2011.153. Epub 2011 Nov 4.
Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation. This review summarizes research on the family of Grs.
颗粒酶（Grs）是在四分之一个多世纪前被发现的。它们由细胞毒性 T 细胞和自然杀伤细胞产生，并在与靶细胞相互作用时释放。为了研究它们在免疫和炎症中的作用，已经进行了大量的生化、遗传和生物学研究。本文综述了 Grs 家族的研究进展。
