Otolaryngology Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Dysphagia. 2012 Jun;27(2):291-3. doi: 10.1007/s00455-011-9372-y. Epub 2011 Nov 4.
We present a 69-year-old male patient with the macroglossia, dysphagia and generalized edema. He was seen previously by other physicians and diagnosed as hypothyroidism. With thyroid stimulating hormone in normal range, tongue biopsy revealed primary systemic amyloidosis. Amyloidosis is the most common cause of macroglossia. Primary systemic amyloidosis should be suspected when laboratory does not support hypothyroidism especially if the enlarged tongue is firm and additional findings are present.
我们呈现一位 69 岁男性患者，其表现为巨舌、吞咽困难和全身性水肿。他曾被其他医生诊治为甲状腺功能减退症。尽管甲状腺刺激激素处于正常范围，但舌活检显示原发性系统性淀粉样变性。淀粉样变性是巨舌的最常见原因。如果实验室检查不支持甲状腺功能减退症，特别是如果肿大的舌头坚硬且存在其他发现，则应怀疑原发性系统性淀粉样变性。
