Zaiac Martin, Clement Annabelle
Greater Miami Skin & Laser Center,4308 Alton Road, Miami Beach, FL 33140, USA.
J Drugs Dermatol. 2011 Nov;10(11):1240-5.
Actinic cheilitis (AC), a common disorder of the lower lip, should be treated early to prevent progression to invasive squamous cell carcinoma. This study evaluated the safety and efficacy of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) activated by blue light for the treatment of AC. Fifteen patients with clinically evident or biopsy-proven AC received two treatments with ALA PDT with blue light activation. Treatments were spaced three to five weeks apart. Most patients achieved 65% to 75% clearance three to five weeks after the first treatment and all achieved more than 75% clearance one month after the second treatment. Three patients achieved complete clearance. Pain and burning during irradiation were absent or mild. All patients said they would repeat the procedure. ALA PDT with 417 nm blue light is a promising option for the treatment of AC of the lower lip.
光化性唇炎（AC）是下唇的一种常见病症，应尽早治疗以防止发展为浸润性鳞状细胞癌。本研究评估了用蓝光激活的5-氨基酮戊酸（ALA）进行光动力疗法（PDT）治疗AC的安全性和有效性。15例临床症状明显或经活检证实为AC的患者接受了两次蓝光激活的ALA PDT治疗。两次治疗间隔三至五周。大多数患者在首次治疗后三至五周实现了65%至75%的清除率，第二次治疗后一个月所有患者的清除率均超过75%。3例患者实现了完全清除。照射期间无疼痛或仅有轻微灼痛。所有患者均表示愿意重复该治疗过程。417纳米蓝光ALA PDT是治疗下唇AC的一种有前景的选择。
