Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA.
Clin Chest Med. 2011 Dec;32(4):783-97. doi: 10.1016/j.ccm.2011.08.011. Epub 2011 Oct 7.
Standard therapy for early-stage non-small cell lung cancer is lobectomy for patients who are able to tolerate such surgery. However, the risk of postoperative morbidity is not trivial, with a 30% to 40% incidence of postoperative complications and a 1% to 5% incidence of operative mortality. Some patients, though technically resectable, refuse surgery or are considered medically inoperable because of insufficient respiratory reserve, cardiovascular disease, or general frailty. This group is considered either "high risk" or "medically inoperable."
早期非小细胞肺癌的标准治疗方法是对能够耐受此类手术的患者进行肺叶切除术。然而，术后发病率的风险不容忽视，术后并发症的发生率为 30%至 40%，手术死亡率为 1%至 5%。一些患者尽管从技术上讲可以切除，但由于呼吸储备不足、心血管疾病或全身虚弱而拒绝手术或被认为不适合手术。这组患者被认为是“高危”或“医学上无法手术”。
