Pain and Autonomics - Integrative Research, Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany.
Drug Alcohol Depend. 2012 May 1;122(3):253-7. doi: 10.1016/j.drugalcdep.2011.10.005. Epub 2011 Nov 4.
Alcohol withdrawal syndrome is associated with an increased incidence of cardiac arrhythmias and sudden cardiac death. Heart rate turbulence (HRT) parameters were applied during withdrawal to estimate cardiac regulation during treatment with clomethiazole.
Twenty-two patients suffering from alcohol withdrawal syndrome were included in the study. Heart rate regulation was obtained by means of Holter ECG analyzing time intervals before medication, and 2 and 6h after medication. Slope and onset of HRT were calculated in addition to heart rate variability (HRV) parameters. Furthermore, we calculated the slope and the onset of ectopic beat-like events.
Heart rate variability parameters indicated a minor reduction of vagal modulation during withdrawal syndrome. Especially, the fractal scaling exponent BBI alpha1 (4-16) indicated the autonomic shift. In contrast to HRV parameters, no significant changes were observed in the HRT parameters. Significant correlations were observed between severity of withdrawal, as assessed by the AWS scale, and the fractal scaling exponent BBI alpha2 (16-64), and the onset and the slope of HRT of ectopic beat-like activity.
Increased sympathetic modulation during withdrawal and clomethiazole treatment is not associated with changes of heart rate turbulence parameters predictive of cardiac death after myocardial infarction.
酒精戒断综合征与心律失常和心源性猝死的发生率增加有关。心率震荡（HRT）参数可用于评估氯美噻唑治疗期间的心脏调节。
研究纳入 22 例患有酒精戒断综合征的患者。通过动态心电图分析药物治疗前、治疗后 2 小时和 6 小时的时间间隔来获得心率调节。除了心率变异性（HRV）参数外，还计算了 HRT 的斜率和起始。此外，我们还计算了异位搏动样事件的斜率和起始。
心率变异性参数表明，在戒断综合征期间，迷走神经调节略有减少。特别是，分形标度指数 BBI alpha1（4-16）表明自主神经转移。与 HRV 参数相比，HRT 参数没有观察到显著变化。AWS 评分评估的戒断严重程度与分形标度指数 BBI alpha2（16-64）、异位搏动样活动的起始和斜率之间存在显著相关性。
在戒断和氯美噻唑治疗期间，交感神经调节增加与心肌梗死后预测心源性猝死的心率震荡参数变化无关。
