Eckert F, Knestele M, Kaudewitz P, Schmoeckel C
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
Hautarzt. 1990 Jul;41(7):378-83.
Encapsulated neuroma of the skin is a little known, though not especially rare, benign tumour of the peripheral nerve system. It is often wrongly diagnosed on the basis of both clinical and histological investigation. We have subjected 24 encapsulated neuromas to clinical, histological, and immunohistological study. Clinically, they presented as solitary, skin-coloured small nodules, usually located on the face in middle-aged adults. Histologically, encapsulated neuromas are well-circumscribed dermal tumours. They are composed of interlacing fascicles of Schwann cells (S-100 protein +) and numerous tiny axons (S-100 protein +, neurofilament +). Most reveal at least partial encapsulation with perineurial differentiation (EMA +, vimentin +). Encapsulated neuromas can be differentiated from other tumours of the peripheral nerve system and from leiomyoma by their distinctive histological and immunohistological features.
皮肤包裹性神经瘤是一种鲜为人知但并非特别罕见的周围神经系统良性肿瘤。基于临床和组织学检查，它常常被误诊。我们对24例皮肤包裹性神经瘤进行了临床、组织学和免疫组织学研究。临床上，它们表现为孤立的、肤色小结节，通常位于中年成人的面部。组织学上，皮肤包裹性神经瘤是边界清楚的真皮肿瘤。它们由施万细胞（S-100蛋白阳性）的交错束和许多微小轴突（S-100蛋白阳性、神经丝蛋白阳性）组成。大多数显示至少部分有束膜分化的包膜（上皮膜抗原阳性、波形蛋白阳性）。皮肤包裹性神经瘤可通过其独特的组织学和免疫组织学特征与周围神经系统的其他肿瘤及平滑肌瘤相鉴别。
