Dipartimento di Scienze della Terra, Sapienza Università di Roma, Rome, Italy.
Anal Bioanal Chem. 2012 Jan;402(2):871-81. doi: 10.1007/s00216-011-5525-y. Epub 2011 Nov 6.
Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe(2+) at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity).
对来自意大利和美国产地的温石棉以及国际癌症研究机构（UICC）青石棉的化学活性与铁含量、氧化态和结构配位进行了研究。在温石棉结构的暴露 M(1)和 M(2)位的 Fe(2+)数量与纤维化学活性之间建立了直接相关性。对相同样品进行了体外细胞毒性研究，研究对象为人肺泡 A549 细胞系。晶体化学特征与细胞毒性之间的关系并不直接。UICC 青石棉的铁含量和化学活性远远高于温石棉样品，但体外毒性相当。研究结果表明，铁的拓扑化学不是诱导细胞毒性的主要因素，尽管它解释了石棉的化学活性（可能还有遗传毒性）。
