钯（II）催化的环丙烷的对映选择性 C-H 活化。
Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes.
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
J Am Chem Soc. 2011 Dec 14;133(49):19598-601. doi: 10.1021/ja207607s. Epub 2011 Nov 21.
Abstract
Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.
摘要
系统的配体开发已经导致了新型单 N-保护氨基酸配体的鉴定，用于 Pd(II)催化的环丙烷的对映选择性 C-H 活化。各种有机硼试剂可用作偶联试剂，反应在温和条件下进行。这些结果为构建对映富集的顺式取代环丙烷羧酸提供了新的逆合成切断。
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