Stankiewicz A, Wrona M
Zakładu Diagnostyki Laboratoryjine Instytutu Medycyny Pracy w Lodzi.
Wiad Lek. 1990 Apr 15;43(8):343-7.
In the light of reports in the literature the data are presented on the importance of glucose-6-phosphate dehydrogenase in cell metabolism. The effect of decreased enzyme activity or its complete absence on the functions of the cell, and the clinical conditions associated with deficient enzyme activity are described. The influence is discussed of the genetic determination of the enzyme on the occurrence of phenotypic effects, and the use of the mosaicism phenomenon in the study on the pathogenesis of certain disturbances. Several reports from the literature are quoted concerning the study of the reverse relationship between a deficiency of the activity of the enzyme and the incidence of carcinoma. The necessity is stressed of including electrophoretic techniques into the studies.
根据文献报道，本文给出了有关葡萄糖-6-磷酸脱氢酶在细胞代谢中的重要性的数据。描述了酶活性降低或完全缺乏对细胞功能的影响，以及与酶活性缺乏相关的临床病症。讨论了酶的遗传决定因素对表型效应发生的影响，以及镶嵌现象在某些紊乱发病机制研究中的应用。引用了文献中几篇关于酶活性缺乏与癌症发病率之间反向关系研究的报道。强调了在研究中纳入电泳技术的必要性。
