Caudy Amy A
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Methods Mol Biol. 2011;772:233-41. doi: 10.1007/978-1-61779-228-1_13.
New technologies for DNA sequencing have made it feasible to determine the genome sequence of any organism of interest. This sequence is the resource required to create tools for downstream studies, including DNA microarrays. A number of vendors can produce DNA microarrays containing customer-specified sequences, allowing investigators to design and order arrays customized for any species of interest. Freely available, user-friendly computer programs are available for designing microarray probes. These design programs can be used to create probes that distinguish between two related genomes, allowing investigation of gene expression or gene representation in intra- or interspecies hybrids or in samples containing DNA from multiple species.
DNA测序新技术使确定任何感兴趣生物体的基因组序列成为可能。该序列是创建用于下游研究工具（包括DNA微阵列）所需的资源。许多供应商可以生产包含客户指定序列的DNA微阵列，使研究人员能够设计和订购为任何感兴趣物种定制的阵列。有免费且用户友好的计算机程序可用于设计微阵列探针。这些设计程序可用于创建能够区分两个相关基因组的探针，从而可以研究种内或种间杂种或含有多个物种DNA的样本中的基因表达或基因表现。
