Ohe Masashi, Hashino Satoshi
Department of General Medicine, Hokkaido Social Insurance Hospital, Sapporo, Japan.
Korean J Hematol. 2011 Sep;46(3):203-6. doi: 10.5045/kjh.2011.46.3.203. Epub 2011 Sep 30.
We report a case of follicular B-cell lymphoma (FL) treated successfully using clarithromycin (CAM). A 44-year-old man who presented with lymphadenopathy was diagnosed with FL after a histological examination of his biopsy specimens. He was administered chemotherapy with R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) following which stable disease was achieved. However, the subsequent clinical course showed partial remission of FL and stable disease with tumor regrowth, each of which was treated with chemotherapeutic regimens. Since the patient was diagnosed with leukocytopenia, he could not undergo chemotherapy for the third regrowth; hence, he was administered CAM. His lymphadenopathy regressed and the levels of soluble interleukin 2-receptor decreased. This case shows that treatment using CAM may be effective in some cases of FL.
我们报告了一例使用克拉霉素（CAM）成功治疗的滤泡性B细胞淋巴瘤（FL）病例。一名44岁出现淋巴结病的男性在对其活检标本进行组织学检查后被诊断为FL。他接受了R-CHOP（利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松龙）化疗，随后病情稳定。然而，随后的临床病程显示FL部分缓解且病情稳定，但肿瘤有复发，每次复发均采用化疗方案治疗。由于该患者被诊断为白细胞减少症，第三次复发时无法进行化疗；因此，给他使用了CAM。他的淋巴结病消退，可溶性白细胞介素2受体水平下降。该病例表明，在某些FL病例中，使用CAM治疗可能有效。
