实验性急性肾小管坏死中99mTc-HEDP的肾内高浓度聚集
Renal hyperconcentration of 99mTc-HEDP in experimental acute tubular necrosis.
作者信息
Lavelle K J, Park H M, Moseman A M, Lewis S
出版信息
Radiology. 1979 May;131(2):491-5. doi: 10.1148/131.2.491.
The effect of transient renal ischemia on renal concentration and distribution of 99mTc-HEDP, 99mTc-DMSA, and 99mTc-DTPA was compared in rabbits with acute tubular necrosis. Scintigrams were obtained after injection in normal rabbits or ones with unilateral or bilateral ischemia. 99mTc-HEDP concentration in ischemic tissue was 8 to 18 times normal 1--4 hours after injection, and the resulting images delineated the morphological changes in the ischemic kidneys more accurately than those obtained with DMSA or DTPA. Calcium concentration in the ischemic kidneys increased sixfold. 99mTc-HEDP may be useful in evaluation of renal failure secondary to tubular injury.
在患有急性肾小管坏死的兔子中，比较了短暂性肾缺血对99m锝-羟乙二膦酸盐（99mTc-HEDP）、99m锝-二巯基丁二酸（99mTc-DMSA）和99m锝-二乙三胺五乙酸（99mTc-DTPA）在肾脏中的浓聚和分布的影响。在正常兔子或单侧或双侧缺血的兔子注射后获取闪烁扫描图像。注射后1至4小时，缺血组织中99mTc-HEDP的浓聚是正常浓聚的8至18倍，并且由此产生的图像比用DMSA或DTPA获得的图像更准确地描绘了缺血肾脏的形态变化。缺血肾脏中的钙浓度增加了六倍。99mTc-HEDP可能有助于评估继发于肾小管损伤的肾衰竭。
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