通过定量计算机断层扫描和临床化学对灵长类动物模型（狨猴）的骨代谢进行分析。
Analysis of the bone metabolism by quantitative computer tomography and clinical chemistry in a primate model (Callithrix jacchus).
作者信息
Grohmann J, Kuehnel F, Buchwald U, Koeller G, Habla C, Einspanier A
机构信息
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany.
出版信息
J Med Primatol. 2012 Feb;41(1):1-10. doi: 10.1111/j.1600-0684.2011.00522.x. Epub 2011 Nov 9.
BACKGROUND
Common marmosets are widely used as experimental primates; however, little is still known about their bone physiology. Therefore, the aim of our study was to analyse body weight, age and bone-specific blood parameters in relation to morphological bone parameters.
METHODS
Fifty-eight common marmosets were analysed for blood calcium (Ca), inorganic phosphor (P(i) ), alkaline phosphatase (AP) and 17-β-estradiol (E2). The examination of bone parameters was undertaken in the lumbar spine by computer tomography.
RESULTS
There was a correlation between bone mineral density (BMD) and body weight, trabecular area ratio and polar moment as well as between BMD and AP or Ca (only males), whereas there were no correlations between BMD and age, P(i) or E2 in all analysed genders.
CONCLUSIONS
Our data support the assumption that the common marmoset is a reliable primate model to study changes in bone metabolism because of the similarity of our results to humans.
背景
普通狨猴被广泛用作实验灵长类动物；然而，关于它们的骨骼生理学仍知之甚少。因此，我们研究的目的是分析体重、年龄和骨特异性血液参数与骨骼形态参数之间的关系。
方法
对58只普通狨猴进行血钙（Ca）、无机磷（P(i)）、碱性磷酸酶（AP）和17-β-雌二醇（E2）的分析。通过计算机断层扫描对腰椎的骨骼参数进行检查。
结果
骨密度（BMD）与体重、小梁面积比和极矩之间存在相关性，并且在BMD与AP或Ca之间（仅雄性）存在相关性，而在所有分析的性别中，BMD与年龄、P(i)或E2之间均无相关性。
结论
我们的数据支持这样的假设，即普通狨猴是研究骨代谢变化的可靠灵长类动物模型，因为我们的结果与人类相似。
Zotero 插件