Ando A, Doishita K, Sanada S, Ando I, Mori H, Hiraki T, Hisada K
Radioisotopes. 1977 Sep;26(9):619-23. doi: 10.3769/radioisotopes.26.9_619.
Serial macroautoradiograms were obtained to determine the distribution of 203Hg-chlormerodrin, 203Hg-nigrate and 99mTc-DMSA in kidney. In the study, normal rats were used and these three radiopharmaceuticals were injected intravenously. Initial images of 203Hg-chlormerodrin showed the accumulation in the outer cortex, but no significant radioactivity in the medullary. On the other hand, delayed images revealed radioactivity shifting in concentration from the outer cortex to the inner cortex. Distribution pattern of 203Hg-nitrate was similar to that of 203Hg-chlormerodrin. In contrast to 203Hg-chlormerodrin and 203Hg-nitrate, 99mTc-DMSA was retained in the outer cortex without temporal changes in the distribution.
获取了连续的宏观放射自显影片，以确定203汞-氯汞君、203汞-硝酸盐和99m锝-二巯基丁二酸在肾脏中的分布。在该研究中，使用了正常大鼠，并通过静脉注射这三种放射性药物。203汞-氯汞君的初始图像显示在外皮质中有积聚，但髓质中无明显放射性。另一方面，延迟图像显示放射性浓度从外皮质向内皮质转移。203汞-硝酸盐的分布模式与203汞-氯汞君相似。与203汞-氯汞君和203汞-硝酸盐相反，99m锝-二巯基丁二酸保留在外皮质中，分布无时间变化。
