手性末端 1,3-二炔与芳香酮的催化对映选择性加成：手性非外消旋三级醇的易得途径。
Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols.
机构信息
Department of Chemistry, Tianjin University, Tianjin 300072, China.
出版信息
Chem Commun (Camb). 2011 Dec 28;47(48):12873-5. doi: 10.1039/c1cc15968b. Epub 2011 Nov 9.
PMID:22068909
Abstract
An efficient, catalytic, and enantioselective 1,2-addition of terminal 1,3-diynes to aromatic ketones was realized in the presence of 10 mol% of a Cu(OTf)(2)-hydroxycamphor-sulfonamide complex, affording chiral tertiary alcohols in up to 94% yield and 90% ee.
摘要
在 10 mol%的 Cu(OTf)(2)-hydroxycamphor-sulfonamide 配合物存在下，实现了末端 1,3-二炔与芳香酮的高效、催化和对映选择性 1,2-加成，以高达 94%的收率和 90%的对映选择性得到手性叔醇。
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