手性仿生催化β-酮酸与三氟甲基酮的脱羧对映选择性Aldol 反应。
Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones.
机构信息
Department of Chemistry, Tianjin University, Tianjin 300072, China.
出版信息
Chem Commun (Camb). 2012 May 7;48(36):4308-10. doi: 10.1039/c2cc30949a.
PMID:22472878
Abstract
We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)(2)AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.
摘要
我们公开了一种在双（金鸡纳）碱（DHQD）（2）AQN 的存在下，β-酮酸与三氟甲基酮的有机催化对映选择性脱羧酮醇醛缩合反应，以高达 98%的收率和 90%的对映体过量值得到手性叔醇。
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