Naydenov Nayden G, Ivanov Andrei I
Department of Medicine; University of Rochester; Rochester, NY USA.
Bioarchitecture. 2011 Jul;1(4):186-191. doi: 10.4161/bioa.1.4.17642. Epub 2011 Jul 1.
Adherens junctions (AJs) and tight junctions (TJs) represent key adhesive structures that regulate the apico-basal polarity and barrier properties of epithelial layers. AJs and TJs readily undergo disassembly and reassembly during normal tissue remodeling and disruption of epithelial barriers in diseases. Such junctional plasticity depends on the orchestrated dynamics of the plasma membrane with its underlying F-actin cytoskeleton, however the interplay between these cellular structures remains poorly understood. Recent studies highlighted the spectrin-adducin-based membrane skeleton as an emerging regulator of AJ and TJ integrity and remodeling. Here we discuss new evidences implicating adducin, spectrin and other membrane skeleton proteins in stabilization of epithelial junctions and regulation of junctional dynamics. Based on the known ability of the membrane skeleton to link cortical actin filaments to the plasma membrane, we hypothesize that the spectrin-adducin network serves as a critical signal and force transducer from the actomyosin cytoskeleton to junctions during remodeling of AJs and TJs.
黏着连接(AJs)和紧密连接(TJs)是关键的黏附结构,可调节上皮层的顶-基极性和屏障特性。在正常组织重塑以及疾病中上皮屏障破坏期间,AJs和TJs很容易发生拆卸和重新组装。这种连接可塑性取决于质膜及其下方F-肌动蛋白细胞骨架的协调动力学,然而这些细胞结构之间的相互作用仍知之甚少。最近的研究强调基于血影蛋白-内收蛋白的膜骨架是AJ和TJ完整性及重塑的新兴调节因子。在这里,我们讨论了涉及内收蛋白、血影蛋白和其他膜骨架蛋白在上皮连接稳定和连接动力学调节中的新证据。基于膜骨架将皮质肌动蛋白丝连接到质膜的已知能力,我们假设血影蛋白-内收蛋白网络在AJs和TJs重塑过程中作为从肌动球蛋白细胞骨架到连接的关键信号和力传感器。