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具有潜在的赭曲霉毒素病因的存档肾和上尿路肿瘤的核不稳定性的初步研究。

A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology.

机构信息

Centre for Environmental Policy, Imperial College London, London SW7 2AZ, UK.

出版信息

Toxins (Basel). 2010 Mar;2(3):326-40. doi: 10.3390/toxins2030326. Epub 2010 Mar 9.

DOI:10.3390/toxins2030326
PMID:22069587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3153191/
Abstract

DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.

摘要

DNA 倍性测量仅应用于原发性肾细胞癌和关键实验研究员猪赭曲霉毒素病转移瘤的蜡包埋组织，一个对照，以及巴尔干地方性肾病的四个移行细胞癌。原发性肾肿瘤是二倍体，而超二倍体转移瘤处于典型肾细胞癌的较低倍性范围内。三个巴尔干原发性肿瘤表现出广泛的非整倍性，表明明显的核不稳定性，类似于由赭曲霉毒素 A 引起的大鼠肾肿瘤模型。相比之下，假定的职业性赭曲霉毒素病病例的核不稳定性要小得多，与赭曲霉毒素 A 模型不太吻合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/409544ce3039/toxins-02-00326-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/82252a65723b/toxins-02-00326-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/50ba9e151c3d/toxins-02-00326-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/75ddb780e364/toxins-02-00326-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/10f8cb8dcc71/toxins-02-00326-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/744f409d1192/toxins-02-00326-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/409544ce3039/toxins-02-00326-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/82252a65723b/toxins-02-00326-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/50ba9e151c3d/toxins-02-00326-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/75ddb780e364/toxins-02-00326-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/10f8cb8dcc71/toxins-02-00326-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/744f409d1192/toxins-02-00326-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66eb/3153191/409544ce3039/toxins-02-00326-g006.jpg

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Mol Nutr Food Res. 2009 Apr;53(4):467-78. doi: 10.1002/mnfr.200800149.
2
New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor.关于人类肾病和尿路肿瘤中霉菌毒素而非马兜铃酸所起作用的新分子证据和现场证据。
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DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A.
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