Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Toxins (Basel). 2010 Jun;2(6):1445-70. doi: 10.3390/toxins2061445. Epub 2010 Jun 14.
Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified within the past decade. Here, we review the regulation, assembly, and binding properties of the LT B-subunit pentamer and discuss the possible roles of its numerous molecular interactions.
肠产毒性大肠杆菌（ETEC）是全球发病率和死亡率的重要来源。ETEC 释放的一种主要毒力因子是不耐热肠毒素 LT，它在结构和功能上与霍乱毒素相似。LT 由五个携带单个催化活性 A 亚基的 B 亚基组成。LTB 结合单唾液酸神经节苷脂 G（M1），即毒素的宿主受体，但在过去十年中，还发现了 A 型血型糖和大肠杆菌脂多糖与 LT 的相互作用。在这里，我们综述了 LT B 亚基五聚体的调节、组装和结合特性，并讨论了其众多分子相互作用的可能作用。
