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汉福德小型猪的实验性冻伤。III. 汗腺变化。

Experimental frost-bite in Hanford Miniature Swine. III. Sweat gland changes.

作者信息

Schoning P

机构信息

Department of Pathology, College of Veterinary Medicine, Kansas State University, Manhattan 66506.

出版信息

Int J Exp Pathol. 1990 Oct;71(5):713-6.

PMID:2206992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2001977/
Abstract

Frost-bite was produced in five Hanford Miniature Swine by exposure to -75 degrees C air for 1, 3, 5, 10 or 20 min. Biopsies were taken at 0, 3, 6, 12, 24 and 48 h and 1, 2 and 15 weeks. Sweat glands were evaluated microscopically and graded: 0, no change to 5, severe change. Sweat gland changes were mild by 1 h and moderate by 24 h for all freeze groups, except the 1-min freeze group. Severe morphological changes were of two types: degeneration/necrosis and squamous metaplasia. These changes suggest that hyperhidrosis, as a sequel to frost-bite, may be more subjective than real and that squamous cell carcinoma, as a delayed sequel to frost-bite, could originate from sweat glands as well as from the epidermis.

摘要

将五只汉福德小型猪暴露于-75摄氏度的空气中1、3、5、10或20分钟，使其产生冻伤。在0、3、6、12、24和48小时以及1、2和15周时进行活检。对汗腺进行显微镜评估并分级：0级为无变化，5级为严重变化。除1分钟冷冻组外，所有冷冻组的汗腺变化在1小时时为轻度，24小时时为中度。严重的形态学变化有两种类型：变性/坏死和鳞状化生。这些变化表明，作为冻伤后遗症的多汗症可能更多是主观感受而非实际情况，并且作为冻伤延迟后遗症的鳞状细胞癌可能起源于汗腺以及表皮。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/2120906138f9/ijexpath00032-0115-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/7eebca1aa9b8/ijexpath00032-0114-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/2120906138f9/ijexpath00032-0115-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/7eebca1aa9b8/ijexpath00032-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/e01a590d75ba/ijexpath00032-0114-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/86d61a6114df/ijexpath00032-0114-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/6dc43a80b356/ijexpath00032-0114-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/75199d96c6f7/ijexpath00032-0115-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/52679576b68e/ijexpath00032-0115-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/26b8192ed67d/ijexpath00032-0115-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/2001977/2120906138f9/ijexpath00032-0115-d.jpg

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本文引用的文献

1
Local cold injury; a report of sequelae.
AMA Arch Derm. 1955 Oct;72(4):335-47. doi: 10.1001/archderm.1955.03730340033007.
2
Squamous cell carcinoma of the heel developing at site of previous frostbite.足跟部鳞状细胞癌发生于既往冻伤部位。
J R Soc Med. 1982 Sep;75(9):715-8. doi: 10.1177/014107688207500908.
3
Experimental frost-bite in Hanford Miniature Swine. I. Epithelial changes.汉福德小型猪的实验性冻伤。I. 上皮变化。
Br J Exp Pathol. 1989 Feb;70(1):41-9.
4
Carcinoma on old frostbites.
Am J Surg. 1977 Mar;133(3):377-8. doi: 10.1016/0002-9610(77)90549-9.