Laboratoire de Synthèse Organique, CNRS-UMR 7652, Ecole Polytechnique, 91128 Palaiseau Cedex, France.
Org Lett. 2011 Dec 2;13(23):6296-9. doi: 10.1021/ol202798r. Epub 2011 Nov 9.
Functionalized alkylidene-cyclobutanes have been prepared from 2-fluoropyridinyl-6-oxy precursors derived from vinyl cyclobutanols by a radical addition-elimination process. A wide range of functional groups is tolerated, and the alkylidene-cyclobutanes can be further elaborated into cyclopentanones. The limitation of this approach resides in the competition with opening of the cyclobutane ring.
功能化的亚烷基环丁烷已通过自由基加成-消除过程，由来源于乙烯基环丁醇的 2-氟吡啶基-6-氧基前体制备。该方法对各种官能团都具有耐受性，且亚烷基环丁烷可以进一步衍生为环戊酮。该方法的局限性在于与环丁烷环的开环竞争。
