Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, Surrey, UK.
Clin Radiol. 2012 Feb;67(2):114-21. doi: 10.1016/j.crad.2011.06.015. Epub 2011 Nov 8.
To examine the performance of screening units in which a proportion of mammograms were double read using "non-discordant radiographer only (double) reading" (NDROR).
NDROR was used by seven pilot units between 2006 and 2009, and six further units in 2009 only. There were 51 comparison units. Screening performance outcome measures were calculated, and logistic regression was used to compare performance between the pilot and comparison units.
Phase 1 pilot units read between on average 15 and 48% of mammograms per year using NDROR between 2006 and 2009 (median, 33%) and in 2009, phase 2 pilot units used NDROR to read between 4 and 77% of mammograms (median, 34%). The results showed an increase in recall rates in the phase 1 pilot units relative to the comparison units at both prevalent and incident screens (adjusted OR 1.09, 95% CI 1.05, 1.14; and adjusted OR 1.10, 95% CI 1.07, 1.14, respectively). There were also increases in the phase 2 pilot units relative to the comparison units; adjusted OR 1.08 (95% 1.00, 1.17) at prevalent screens, and adjusted OR 1.07 (95% CI 1.02, 1.14) at incident screens. There was no evidence to suggest a difference in cancer-detection rates between the pilot units and the comparison units.
Evidence from the present study suggests that recall rates may increase as a result of units using radiographers to double read a proportion of their mammograms. However, there is little evidence to suggest that NDROR, as practiced by the pilot units in the present study, is likely to have major impacts on performance in the UK National Health Service Breast Screening Programme (NHSBSP), particularly if it is fully supported and closely monitored (particularly recall rates).
研究使用“仅由非不一致的放射技师(双重)阅读(NDROR)”对部分乳房 X 光片进行双重阅读的筛查单位的性能。
2006 年至 2009 年期间,有 7 个试点单位使用 NDROR,2009 年仅有 6 个单位使用。有 51 个对照单位。计算筛查性能指标,并使用逻辑回归比较试点单位和对照单位之间的性能。
第一阶段试点单位在 2006 年至 2009 年间,每年平均使用 NDROR 阅读 15%至 48%的乳房 X 光片(中位数为 33%),而在 2009 年,第二阶段试点单位使用 NDROR 阅读 4%至 77%的乳房 X 光片(中位数为 34%)。结果显示,与对照单位相比,第一阶段试点单位的召回率在现患和新发筛查中均有所增加(调整后的 OR 1.09,95%CI 1.05,1.14;和调整后的 OR 1.10,95%CI 1.07,1.14)。第二阶段试点单位与对照单位相比也有所增加;现患筛查中调整后的 OR 为 1.08(95%置信区间为 1.00,1.17),新发筛查中调整后的 OR 为 1.07(95%置信区间为 1.02,1.14)。没有证据表明试点单位和对照单位之间的癌症检出率存在差异。
本研究的证据表明,由于单位使用放射技师对一部分乳房 X 光片进行双重阅读,召回率可能会增加。然而,几乎没有证据表明,NDROR (如本研究中试点单位所实施的那样)可能对英国国家卫生服务乳房筛查计划(NHSBSP)的性能产生重大影响,特别是如果它得到充分支持和密切监测(特别是召回率)。