Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, FL, USA.
Am J Obstet Gynecol. 2011 Sep;205(3):275.e1-5. doi: 10.1016/j.ajog.2011.06.043. Epub 2011 Jun 17.
We sought to compare rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17-α-hydroxyprogesterone caproate (17P) with prior SPTB due to preterm labor (PTL) vs preterm premature rupture of membranes (PPROM).
Women with singleton gestation having 1 prior SPTB enrolled at 16-24.9 weeks' gestation for weekly outpatient 17P administration were identified from a database. Rates of recurrent SPTB were compared between those with prior SPTB due to PTL or PPROM overall and by gestational age at prior SPTB.
Records from 2123 women were analyzed. The prior PTL group vs the prior PPROM group experienced higher rates of recurrent SPTB at <37 weeks (29.7% vs 22.9%, P = .004), <35 weeks (14.0% vs 9.1%, P = .004), and <32 weeks (5.9% vs 3.3%, P = .024), respectively.
Reason and gestational age of prior SPTB influence the likelihood of recurrent SPTB in women receiving 17P prophylaxis.
我们旨在比较因早产临产（PTL）和胎膜早破（PPROM）而发生既往自发性早产（SPTB）的女性接受 17-α-羟孕酮己酸酯（17P）治疗后的复发性 SPTB 发生率。
从数据库中确定了在 16-24.9 孕周进行每周门诊 17P 给药的单胎妊娠且有 1 次既往 SPTB 的女性。比较了既往因 PTL 或 PPROM 而发生 SPTB 的患者之间以及既往 SPTB 时的妊娠年龄之间的复发性 SPTB 发生率。
分析了 2123 名女性的记录。与既往因 PPROM 而发生 SPTB 的患者相比，既往因 PTL 而发生 SPTB 的患者在<37 孕周（29.7% vs. 22.9%，P =.004）、<35 孕周（14.0% vs. 9.1%，P =.004）和<32 孕周（5.9% vs. 3.3%，P =.024）的复发性 SPTB 发生率更高。
既往 SPTB 的原因和妊娠年龄会影响接受 17P 预防的女性发生复发性 SPTB 的可能性。
