al-Humayyd M S
Department of Medical Pharmacology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Biopharm Drug Dispos. 1990 Jul;11(5):411-7. doi: 10.1002/bdd.2510110506.
The effect of diltiazem on the plasma level of carbamazepine (CBZ) was investigated in rabbits. The animals were given either CBZ alone or in combination with diltiazem and plasma samples were collected at different time intervals. The concentration of CBZ was detected using an HPLC method. Diltiazem significantly increased the area under the curve (AUC), the maximum plasma concentration (Cmax), and the elimination half-life (t1/2) of CBZ (p less than 0.05). These results suggest that a potentially harmful drug-drug interaction may occur if CBZ and diltiazem are administered concurrently.
在兔身上研究了地尔硫䓬对卡马西平（CBZ）血浆水平的影响。给动物单独给予CBZ或与地尔硫䓬联合给药，并在不同时间间隔采集血浆样本。使用高效液相色谱法检测CBZ的浓度。地尔硫䓬显著增加了CBZ的曲线下面积（AUC）、最大血浆浓度（Cmax）和消除半衰期（t1/2）（P<0.05）。这些结果表明，如果同时给予CBZ和地尔硫䓬，可能会发生潜在有害的药物相互作用。
