Rajantie Jukka
HYKS, pediatrian klinikkaryhmä, Jorvin sairaala.
Duodecim. 2011;127(19):2081-6.
Thrombocytopenia associated with ITP in children usually returns to normal within a couple of months. Drug therapies are required to treat hemorrhages in approximately one fifth of the patients. Intravenously infused immunoglobulin is effective more rapidly than corticosteroid therapy, but the treatment response is mostly temporary. Thrombocytopenia is alleviated by splenectomy in approx. 70% of chronic ITP patients. In the absence of primary disease causing thrombocytopenia, splenectomy has to be contemplated, if thrombocytopenia impairs the quality of life for more than one year. New drug therapies such as rituximab and growth factor products increasing thrombopoiesis may decrease the number of splenectomies.
儿童特发性血小板减少性紫癜（ITP）相关的血小板减少症通常在几个月内恢复正常。约五分之一的患者需要药物治疗来治疗出血。静脉输注免疫球蛋白比皮质类固醇疗法起效更快，但治疗反应大多是暂时的。约70%的慢性ITP患者行脾切除术后血小板减少症得到缓解。在没有引起血小板减少症的原发性疾病的情况下，如果血小板减少症对生活质量的影响超过一年，就必须考虑行脾切除术。利妥昔单抗和增加血小板生成的生长因子产品等新药疗法可能会减少脾切除术的数量。
