Dannaher C L, Yam L T, McKeown J M
South Med J. 1979 May;72(5):622-4. doi: 10.1097/00007611-197905000-00034.
Carcinoma metastatic to the bone marrow may present with peripheral blood and bone marrow changes and a clinical picture difficult to distinguish from leukemia. It is important to make an accurate diagnosis since the management is different. We have described a patient with circulating primitive cells and diffuse marrow involvement by similar cells. The pathologic process may be identified without cell markers by careful attention to the pattern of distribution, as well as the cytologic features of the neoplastic cells in the bone marrow biopsy.
骨髓转移性癌可能表现为外周血和骨髓改变，以及难以与白血病相鉴别的临床表现。由于治疗方法不同，准确诊断很重要。我们描述了一位患者，其外周血中有原始细胞，骨髓中也有类似细胞弥漫性浸润。通过仔细观察骨髓活检中肿瘤细胞的分布模式和细胞学特征，无需细胞标志物即可识别病理过程。
