Kekunnaya Ramesh, Gupta Amit, Sachdeva Virender, Krishnaiah Sannapaneni, Venkateshwar Rao B, Vashist Urvish, Ray Debajit
Jasti V Ramanamma Children’s Eye Care Center and Department of Epidemiology and Biostatistics, L V Prasad Eye Institute, KAR Campus, Banjara Hills, Hyderabad, India.
J Pediatr Ophthalmol Strabismus. 2012 May-Jun;49(3):164-9. doi: 10.3928/01913913-20111101-01. Epub 2011 Nov 8.
To determine the demographic and clinical profile of various subtypes of Duane retraction syndrome (DRS).
Retrospective case series of 441 patients.
Of the total 441 patients, 389 (88.2%) and 52 (11.8%) patients had unilateral and bilateral involvement, respectively. In both unilateral and bilateral cases, type I was the most common subtype, followed by types III and II. Mean age of presentation of type I DRS was significantly less (13.3 years) compared with types II (23 years) and III (21.9 years) (P < .05). Unilateral disease was significantly more common in females (57. 6%, P = .006), whereas there was no gender predilection in bilateral cases (P = .77). Type 1 DRS was significantly more common among females (57.96%, P = .003) compared with males, whereas there was no such gender predilection in types II and III. The left eye was more commonly involved in patients with types I and III (P < .05), whereas in type II there was no such predilection for any eye involvement. Esotropia was more common in patients with bilateral disease (53.8%) and exotropia was predominant ocular deviation in patients with types II and III (70% and 66.67%, P = .03). There was no difference in the type of deviation in patients with type I (P > .05). Upshoots and downshoots were more common in unilateral disease and types I and III compared with type II.
Unilateral and bilateral DRS show considerable differences in gender distribution, associated ocular deviation, overshoots, and ocular and systemic associations.
确定杜安眼球后退综合征（DRS）各亚型的人口统计学和临床特征。
对441例患者进行回顾性病例系列研究。
在总共441例患者中，分别有389例（88.2%）和52例（11.8%）为单侧和双侧受累。在单侧和双侧病例中，I型是最常见的亚型，其次是III型和II型。I型DRS的平均发病年龄（13.3岁）明显低于II型（23岁）和III型（21.9岁）（P <.05）。单侧疾病在女性中明显更常见（57.6%，P =.006），而双侧病例中无性别倾向（P =.77）。与男性相比，I型DRS在女性中明显更常见（57.96%，P =.003），而II型和III型则无此类性别倾向。I型和III型患者中左眼受累更常见（P <.05），而II型中无任何眼受累倾向。内斜视在双侧疾病患者中更常见（53.8%），外斜视是II型和III型患者的主要眼位偏斜（分别为70%和66.67%，P =.03）。I型患者的偏斜类型无差异（P >.05）。与II型相比，上睑上抬和下落现象在单侧疾病以及I型和III型中更常见。
单侧和双侧DRS在性别分布、相关眼位偏斜、上睑过升、眼与全身关联方面存在显著差异。
