去甲丙咪嗪可阻断应激诱导的大鼠催乳素释放：中枢β-2肾上腺素能受体的作用。

Desipramine blocks stress-induced prolactin release in rats: role of central beta-2 adrenoceptors.

de-Castro-e-Silva E, Ramalho M J, Midlej M, Cobas C, Machado A, Antunes-Rodrigues J

Departamento de Fisiologia, Universidade Federal da Bahia, Salvador, BA, Brasil.

Braz J Med Biol Res. 1990;23(2):199-204.

Abstract

The present study was designed to examine the relationship between beta-adrenoceptors and the enhanced, sustained prolactin secretion induced by immobilization stress in rats. 2. Chronic administration of desipramine (15 mg kg-1 day-1, intraperitoneally) for 7 days, a procedure that desensitizes central beta-adrenoceptors, partially inhibits stress-induced prolactin release. 3. Intracerebroventricular administration of the beta-2 adrenoceptor agonist salbutamol (1 microgram/rat) to rats pretreated with desipramine for 7 days, 15 min before immobilization, significantly relieved the inhibition by desipramine 5 and 10 min after the initiation of stress but the effect was not demonstrable after 20 and 40 min. 4. We conclude that beta-2 adrenoceptors play a role in the control of prolactin release in response to stress.

摘要

本研究旨在探讨大鼠β-肾上腺素能受体与固定应激诱导的催乳素分泌增强及持续分泌之间的关系。2. 连续7天腹腔注射去甲丙咪嗪（15毫克/千克/天），该过程使中枢β-肾上腺素能受体脱敏，部分抑制应激诱导的催乳素释放。3. 对用去甲丙咪嗪预处理7天的大鼠，在固定前15分钟脑室内注射β-2肾上腺素能受体激动剂沙丁胺醇（1微克/大鼠），在应激开始后5分钟和10分钟时显著减轻了去甲丙咪嗪的抑制作用，但在20分钟和40分钟后该作用未得到证实。4. 我们得出结论，β-2肾上腺素能受体在应激反应中催乳素释放的控制中发挥作用。