Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital of Iceland, Reykjavik, Iceland.
Dig Dis Sci. 2012 Jul;57(7):1959-64. doi: 10.1007/s10620-011-1950-1. Epub 2011 Nov 11.
Statin drugs are widely used worldwide and are generally considered safe and well tolerated. Only small proportion of patients receiving statins develop elevations of liver enzymes and an even smaller proportion will have clinically significant hepatitis induced by statins. We describe four patients with jaundice caused by drug-induced liver injury, where the most likely agent was a statin drug, over a period of approximately three year in Iceland. We calculate the risk of jaundice caused by statin drugs, from sale in the whole country of Iceland, to be one in 17,434 users a year. This is a higher risk than has previously been estimated and we challenge the current opinion that statins rarely cause clinically significant drug-induced liver injury and encourage alertness when managing patients with statins with regard to clinical signs of hepatitis before jaundice occurs.
他汀类药物在全球范围内广泛使用，通常被认为是安全且耐受良好的。只有一小部分接受他汀类药物治疗的患者会出现肝酶升高，而更少的患者会因他汀类药物引起临床显著的肝炎。我们描述了在冰岛大约三年的时间里，四例由药物性肝损伤引起的黄疸患者，最有可能的药物是他汀类药物。我们计算了冰岛全国范围内他汀类药物引起黄疸的风险，每年每 17434 名使用者中就有一例。这一风险高于之前的估计，我们质疑目前他汀类药物很少引起临床显著的药物性肝损伤的观点，并在出现黄疸之前管理使用他汀类药物的患者时，鼓励对肝炎的临床体征保持警惕。
