Wiegering V, Girschick H J, Morbach H
Pediatric Hematology, Oncology and Neurooncology, Pediatric Stem Cell Transplantation Program, Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Arthritis. 2010;2010:759868. doi: 10.1155/2010/759868. Epub 2010 Dec 2.
Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.
幼年特发性关节炎（JIA）是儿童和青少年慢性关节炎最常见的病因，涵盖了一组异质性的不同疾病。由于B细胞耗竭疗法在类风湿性关节炎中取得了令人鼓舞的结果，因此必须在新的背景下讨论B细胞在自身免疫性疾病中的作用。此外，小鼠模型实验为B细胞在自身免疫性疾病发展中的非抗体依赖性作用提供了新的线索。在本综述中，我们将讨论B细胞在JIA发病机制中的重要性，评估JIA中B细胞靶向治疗免疫学基础的问题。
