Clin Rheumatol. 2009 Dec;28(12):1461-3. doi: 10.1007/s10067-009-1282-0. Epub 2009 Sep 30.
A broad range of autoantibodies have been detected in juvenile chronic arthritis (JCA) patients, although, none of them can be considered specific for this entity. Antinuclear antibody (ANA) is routinely searched in these patients mainly because it is associated with uveitis, a comorbidity that is particularly frequent in the oligoarticular form. Nevertheless, the ANA specific antigen target in JCA is unknown. In this study, we aimed to search for antinucleosome antibodies in 30 adult JCA patients and to study possible associations with clinical profile. Ten individuals (33.3%) were positive for antinucleosome antibodies and seven (70%) were simultaneously ANA positive (p = 0.01). We did not find any significant association among antinucleosome and JCA form, uveitis, age of onset, gender, or functional index. We conclude that in JCA, there is a prevalence of 33.3% of antinucleosome antibodies. Further investigations are needed to understand the ANA positivity found in this disease as far as the clinical impact of this finding.
在幼年特发性关节炎（JCA）患者中已经检测到广泛的自身抗体，但没有一种可以被认为是该疾病特有的。在这些患者中，常规检测抗核抗体（ANA）主要是因为它与葡萄膜炎有关，葡萄膜炎是寡关节炎型 JCA 的一种特别常见的合并症。然而，JCA 中 ANA 的特定抗原靶标尚不清楚。在这项研究中，我们旨在检测 30 名成年 JCA 患者中的抗核小体抗体，并研究其与临床特征的可能关联。有 10 名患者（33.3%）抗核小体抗体阳性，其中 7 名（70%）同时 ANA 阳性（p=0.01）。我们没有发现抗核小体与 JCA 类型、葡萄膜炎、发病年龄、性别或功能指数之间存在任何显著关联。我们得出结论，在 JCA 中，抗核小体抗体的患病率为 33.3%。需要进一步的研究来了解该疾病中发现的 ANA 阳性，以及这一发现的临床意义。
