Hacettepe University, Faculty of Medicine, Department of Radiation Oncology, Ankara, Turkey.
Head Neck. 2013 Mar;35(3):E69-73. doi: 10.1002/hed.21895. Epub 2011 Nov 11.
Sinonasal mucosal melanoma (SNMM) is a rare entity originating from melanocytes of the sinonasal mucosa. Postoperative radiotherapy is recommended in all cases to increase local control. However, external radiotherapy is rarely used as a definitive treatment modality. In this report, we present 4 cases of SNMM treated with CyberKnife (Accuray, Sunnyvale, CA).
All patients were immobilized with a thermoplastic mask. A planning CT scan with 1-mm thickness was obtained, and these images were fused with MRI for the contouring procedure. Multiplan (Accuray) inverse planning software was used for treatment planning. Robotic stereotactic body radiotherapy (SBRT) was delivered with CyberKnife.
Median follow-up was 26 months. Three patients had complete response to CyberKnife, and 1 patient had partial response.
Robotic SBRT seems to be an appealing treatment option for local control. Effective systemic treatment is required to prevent distant metastases.
鼻腔鼻窦黏膜黑色素瘤（SNMM）是一种罕见的实体瘤，起源于鼻腔鼻窦黏膜的黑色素细胞。所有病例均推荐术后放疗以提高局部控制率。然而，外部放疗很少作为一种确定性的治疗方式。在本报告中，我们介绍了 4 例采用 CyberKnife（Accuray，加利福尼亚州森尼韦尔）治疗的 SNMM 病例。
所有患者均采用热塑面罩固定。进行了 1 毫米厚的计划 CT 扫描，并将这些图像与 MRI 融合进行轮廓勾画。使用多计划（Accuray）逆向计划软件进行治疗计划。采用 CyberKnife 进行机器人立体定向体部放疗（SBRT）。
中位随访时间为 26 个月。3 例患者对 CyberKnife 有完全缓解，1 例患者有部分缓解。
机器人 SBRT 似乎是一种有吸引力的局部控制治疗选择。需要有效的全身治疗以预防远处转移。
