Center for Clinical Pharmacology, University Hospital Gasthuisberg, Leuven, Belgium.
Headache. 2012 Mar;52(3):433-40. doi: 10.1111/j.1526-4610.2011.02030.x. Epub 2011 Nov 11.
To compare binding of the type 1 cannabinoid receptor (CB1R) between migraine patients and healthy volunteers.
It has been suggested that endocannabinoid deficiency may play a role in the pathophysiology of migraine. Nonetheless, biochemical studies substantiating this idea remain scarce and are faced with methodological shortcomings partly because of the difficulty to perform measurements of endocannabinoids within the central nervous system itself.
An observational cross-sectional study was conducted in 20 female migraine patients and 18 healthy women matched for age and body mass index. Positron emission tomography acquisition was performed 90 minutes after intravenous injection of the radioligand [(18)F]MK-9470 to assess binding of [(18)F]MK-9470 to CB1R.
Binding of CB1 R was globally increased in migraine patients vs healthy controls (average gray matter difference +16%; P = .009, 2-sample 2-sided Student's t-test). There were no correlations between CB1R binding and any predefined migraine characteristics. Increases in CB1R binding were most pronounced in the anterior cingulate, mesial temporal, prefrontal, and superior frontal cortices.
The increased interictal CB1R binding, especially in brain regions that exert top-down influences to modulate pain, supports the idea that endocannibinoid deficiency is present in female patients suffering from episodic migraine.
比较偏头痛患者和健康志愿者之间的 1 型大麻素受体 (CB1R) 结合情况。
内源性大麻素缺乏可能在偏头痛的病理生理学中起作用，这一观点已被提出。然而，支持这一观点的生化研究仍然很少，并且由于难以在中枢神经系统本身内进行内源性大麻素的测量，这些研究面临着方法学上的缺陷。
在 20 名女性偏头痛患者和 18 名年龄和体重指数匹配的健康女性中进行了一项观察性横断面研究。静脉注射放射性配体 [(18)F]MK-9470 90 分钟后进行正电子发射断层扫描采集，以评估 [(18)F]MK-9470 与 CB1R 的结合情况。
与健康对照组相比，偏头痛患者的 CB1R 结合普遍增加（平均灰质差异+16%；P=0.009，2 样本双侧学生 t 检验）。CB1R 结合与任何预先定义的偏头痛特征之间均无相关性。CB1R 结合的增加在扣带回前部、内侧颞叶、前额叶和额上回最为明显。
在发作间期 CB1R 结合增加，尤其是在对疼痛进行自上而下调节的大脑区域，支持内源性大麻素缺乏存在于患有阵发性偏头痛的女性患者中的观点。
