Berman J J, Rice J M, Strandberg J
Vet Pathol. 1978 Nov;15(6):725-31. doi: 10.1177/030098587801500604.
A large, intraabdominal rat schwannoma had numerous granule-containing cells cytologically identical to cells of granular cell tumor (myoblastoma). The small eosinophilic granules stained positively by the periodic acid-Schiff (PAS) reaction, with intensity not reduced by diastase pretreatment. Granules stained positively with the Tibor Pap silver impregnation for reticulin and by electron microscopy were identical to myoblastoma cell granules. The nuclei of granular cells were morphologically identical to those of the neoplastic Schwann cells. The granular cells were in numerous foci within the tumor, frequently were seen in mitosis, and possessed an extremely variable volume of cytoplasm. They seemed to evolve from neoplastic Schwann cells. Cells with only a narrow perinuclear rim of granular cytoplasm were of the same size and general configuration as adjacent neoplastic Schwann cells, while cells with increasing volumes of granular cytoplasm were increasingly swollen and round. One area of the tumor was composed almost entirely of such large cells and was histologically identical to classic granular cell tumor.
一只大型腹腔内大鼠神经鞘瘤含有大量含颗粒细胞，其细胞学特征与颗粒细胞瘤（成肌细胞瘤）的细胞相同。小的嗜酸性颗粒经高碘酸-希夫（PAS）反应呈阳性染色，经淀粉酶预处理后强度未降低。颗粒经蒂博尔·帕普（Tibor Pap）网状纤维银浸染呈阳性染色，且通过电子显微镜观察与成肌细胞瘤细胞颗粒相同。颗粒细胞的细胞核在形态上与肿瘤性施万细胞的细胞核相同。颗粒细胞在肿瘤内形成多个病灶，常可见有丝分裂，且细胞质体积变化极大。它们似乎由肿瘤性施万细胞演变而来。仅在核周有狭窄颗粒状细胞质边缘的细胞与相邻肿瘤性施万细胞大小和总体形态相同，而颗粒状细胞质体积不断增加的细胞则越来越肿胀且呈圆形。肿瘤的一个区域几乎完全由这类大细胞组成，在组织学上与经典颗粒细胞瘤相同。
