McCluney Neil, Shakeel Muhammad, Dallas Andrew, Hussain Akhtar, Chapman Andrea
Department of Otolaryngology Head and Neck Surgery, University of Aberdeen, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK.
J Coll Physicians Surg Pak. 2011 Nov;21(11):706-7.
Amyloidosis is an idiopathic disease that is characterized by the extracellular deposition of fibrillar proteins. The disease can be categorized as primary or secondary where deposits occur in conjunction with chronic diseases such as rheumatoid arthritis or tuberculosis. The deposits can be localized or systemically distributed. It can mimic, and also be associated with underlying malignancy. Primary amyloidosis is a rare cause of a nasopharyngeal lesion, and less so of a secondary middle ear effusion. Its association with underlying chronic and malignant disease must not be over-looked if serious complications are to be avoided. It is, therefore, important to consider this as a differential diagnosis in such patients.
淀粉样变性是一种特发性疾病，其特征为细胞外纤维状蛋白沉积。该疾病可分为原发性或继发性，继发性淀粉样变性的沉积物与类风湿性关节炎或结核病等慢性疾病同时出现。沉积物可局限或全身分布。它可模仿潜在恶性肿瘤，也可与之相关。原发性淀粉样变性是鼻咽部病变的罕见病因，更是继发性中耳积液的罕见病因。若要避免严重并发症，就绝不能忽视其与潜在慢性和恶性疾病的关联。因此，将其作为此类患者的鉴别诊断很重要。
