在 9.4T 下检测到未处理大鼠中左旋四氢巴马汀给药对多巴胺能、5-羟色胺能和去甲肾上腺素能网络的反应。
Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naïve rats detected at 9.4 T.
机构信息
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
出版信息
Magn Reson Imaging. 2012 Feb;30(2):261-70. doi: 10.1016/j.mri.2011.09.006. Epub 2011 Nov 12.
Abstract
AIM
The aim of this study was to understand the neuropharmacological characteristics of levo-tetrahydropalmatine (l-THP), a recently found potential treatment for drug addiction, and discover its neural correlates and sites of action.
METHODS
High-field pharmacological magnetic resonance imaging (phMRI) was used to detect activation induced by acute l-THP administration in the naïve rat brain at dose levels of 5, 10, 20 and 40 mg/kg.
RESULTS
Interestingly, the pharmacological profile of l-THP selectively binds to the receptors of the dopaminergic, serotonergic and noradrenergic systems. Using the phMRI method, it was demonstrated that l-THP selectively activated the key brain regions of the dopaminergic, serotonergic and noradrenergic systems in a dose-dependent manner.
CONCLUSION
Numerous studies suggest a critical role of monoamines in the behavioral, pharmacological and addictive properties of psychostimulants. It is suggested that l-THP holds great potential to be a therapeutic medication for drug addiction.
摘要
目的
本研究旨在了解左旋延胡索乙素（l-THP）的神经药理学特性，左旋延胡索乙素是一种新发现的潜在药物成瘾治疗药物，并发现其神经相关和作用部位。
方法
高场药理学磁共振成像（phMRI）用于检测在 5、10、20 和 40 mg/kg 剂量水平下急性 l-THP 给药在未处理大鼠脑中诱导的激活。
结果
有趣的是，l-THP 的药理学特征选择性结合到多巴胺能、5-羟色胺能和去甲肾上腺素能系统的受体。使用 phMRI 方法，证明 l-THP 以剂量依赖性方式选择性激活多巴胺能、5-羟色胺能和去甲肾上腺素能系统的关键脑区。
结论
大量研究表明单胺类物质在精神兴奋剂的行为、药理学和成瘾特性中起着关键作用。因此，l-THP 极有可能成为治疗药物成瘾的药物。
相似文献
1
Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naïve rats detected at 9.4 T.在 9.4T 下检测到未处理大鼠中左旋四氢巴马汀给药对多巴胺能、5-羟色胺能和去甲肾上腺素能网络的反应。
Magn Reson Imaging. 2012 Feb;30(2):261-70. doi: 10.1016/j.mri.2011.09.006. Epub 2011 Nov 12.
2
Differential effect of isoflurane, medetomidine, and urethane on BOLD responses to acute levo-tetrahydropalmatine in the rat.异氟醚、右美托咪定和乌拉坦对急性左旋四氢巴马汀诱导大鼠 BOLD 反应的差异作用。
Magn Reson Med. 2012 Aug;68(2):552-9. doi: 10.1002/mrm.23243. Epub 2011 Dec 28.
3
Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats.口服左甲哌卡因可减轻可卡因、应激或与药物相关线索复燃已消除的可卡因觅药行为。
Drug Alcohol Depend. 2011 Jul 1;116(1-3):72-9. doi: 10.1016/j.drugalcdep.2010.11.023. Epub 2010 Dec 31.
4
Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats.左旋四氢巴马汀可减弱大鼠对可卡因的自我给药行为以及可卡因诱导的复吸。
Psychopharmacology (Berl). 2007 Jul;192(4):581-91. doi: 10.1007/s00213-007-0754-7. Epub 2007 Mar 15.
5
Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement.左旋四氢巴马汀是一种天然的混合型多巴胺受体拮抗剂，可抑制甲基苯丙胺的自我给药及甲基苯丙胺诱导的复吸。
Pharmacol Biochem Behav. 2016 May;144:67-72. doi: 10.1016/j.pbb.2016.01.010. Epub 2016 Jan 21.
6
Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats.左甲素通过递增比例程序减弱大鼠可卡因自身给药和可卡因辨别。
Pharmacol Biochem Behav. 2010 Dec;97(2):310-6. doi: 10.1016/j.pbb.2010.08.016. Epub 2010 Sep 9.
7
Inhibition of acid-sensing ion channels by levo-tetrahydropalmatine in rat dorsal root ganglion neurons.左旋四氢巴马汀对大鼠背根神经节神经元酸敏感离子通道的抑制作用。
J Neurosci Res. 2015 Feb;93(2):333-9. doi: 10.1002/jnr.23484. Epub 2014 Nov 13.
8
The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats.左旋四氢巴马汀作为多巴胺受体拮抗剂，可减弱大鼠海洛因自身给药和海洛因诱导的复吸。
Pharmacol Biochem Behav. 2012 Jul;102(1):1-5. doi: 10.1016/j.pbb.2012.03.014. Epub 2012 Mar 27.
9
Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats.左旋四氢巴马汀通过调节大鼠中ERK和CREB磷酸化的表达来抑制氯胺酮诱导的条件性位置偏爱习得。
Behav Brain Res. 2017 Jan 15;317:367-373. doi: 10.1016/j.bbr.2016.10.001. Epub 2016 Oct 3.
10
Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.左旋四氢巴马汀抑制可卡因的奖赏效应：大鼠自我给药和脑刺激奖赏实验
Neuropharmacology. 2007 Nov;53(6):771-82. doi: 10.1016/j.neuropharm.2007.08.004. Epub 2007 Aug 15.
引用本文的文献
1
Simultaneous Determination of Levo-tetrahydropalmatine and Naltrexone in Rat Plasma by LC-MS/MS and its Application in a Pharmacokinetic Study.LC-MS/MS 法同时测定大鼠血浆中左旋延胡索乙素和纳曲酮的浓度及其药代动力学研究。
Curr Pharm Biotechnol. 2024;25(14):1875-1883. doi: 10.2174/0113892010271975231218074830.
2
A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine.四氢巴马汀的化学性质、植物来源、药理活性、药代动力学及毒理学特性综述
Front Pharmacol. 2022 Apr 26;13:890078. doi: 10.3389/fphar.2022.890078. eCollection 2022.
3
Neural bases for attenuation of morphine withdrawal by Heantos-4: role of l-tetrahydropalmatine.海桐碱 4 减轻吗啡戒断的神经基础：左旋四氢巴马汀的作用。
Sci Rep. 2020 Dec 4;10(1):21275. doi: 10.1038/s41598-020-78083-x.
4
l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats.左旋四氢巴马汀降低大鼠尼古丁自我给药及复吸行为。
BMC Pharmacol Toxicol. 2016 Nov 7;17(1):49. doi: 10.1186/s40360-016-0093-6.
5
Pharmacokinetics and Safety Assessment of l-Tetrahydropalmatine in Cocaine Users: A Randomized, Double-Blind, Placebo-Controlled Study.左旋四氢巴马汀在可卡因使用者中的药代动力学及安全性评估：一项随机、双盲、安慰剂对照研究
J Clin Pharmacol. 2017 Feb;57(2):151-160. doi: 10.1002/jcph.789. Epub 2016 Aug 4.
本文引用的文献
1
Prefrontal cortical regulation of drug seeking in animal models of drug relapse.药物复发动动物模型中前额叶皮质对觅药行为的调控
Curr Top Behav Neurosci. 2010;3:101-17. doi: 10.1007/7854_2009_19.
2
Levo-tetrahydropalmatine attenuates oxycodone-induced conditioned place preference in rats.左旋四氢巴马汀减轻大鼠中羟考酮诱导的条件性位置偏爱。
Eur J Pharmacol. 2009 Jan 14;602(2-3):321-7. doi: 10.1016/j.ejphar.2008.11.031. Epub 2008 Nov 25.
3
Isoflurane anesthesia is a valuable alternative for alpha-chloralose anesthesia in the forepaw stimulation model in rats.在大鼠前爪刺激模型中，异氟烷麻醉是α-氯醛糖麻醉的一种有价值的替代方法。
NMR Biomed. 2009 May;22(4):414-8. doi: 10.1002/nbm.1351.
4
Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse.5-羟色胺5-HT2R药物疗法在精神兴奋剂滥用治疗中的前景
Prog Brain Res. 2008;172:319-46. doi: 10.1016/S0079-6123(08)00916-3.
5
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction.综述：易形成强迫性觅药习惯和成瘾的神经机制。
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3125-35. doi: 10.1098/rstb.2008.0089.
6
Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study.左旋四氢巴马汀治疗可显著改善海洛因使用者的阿片类药物渴求并提高戒断率：一项初步研究。
Acta Pharmacol Sin. 2008 Jul;29(7):781-8. doi: 10.1111/j.1745-7254.2008.00817.x.
7
Behavioral correlates of negative BOLD signal changes in the primary somatosensory cortex.初级体感皮层负性BOLD信号变化的行为相关性。
Neuroimage. 2008 Jul 15;41(4):1364-71. doi: 10.1016/j.neuroimage.2008.03.049. Epub 2008 Apr 8.
8
Functional MRI of the brain detects neuropathic pain in experimental spinal cord injury.大脑功能磁共振成像可检测实验性脊髓损伤中的神经性疼痛。
Pain. 2008 Aug 31;138(2):292-300. doi: 10.1016/j.pain.2007.12.017. Epub 2008 Feb 6.
9
GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI.人类前扣带回皮质中的γ-氨基丁酸（GABA）浓度可预测功能磁共振成像（fMRI）中的负性血氧水平依赖（BOLD）反应。
Nat Neurosci. 2007 Dec;10(12):1515-7. doi: 10.1038/nn2001. Epub 2007 Nov 4.
10
Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium.内感受性脑岛失活可破坏锂诱导的药物渴望和不适。
Science. 2007 Oct 26;318(5850):655-8. doi: 10.1126/science.1145590.
Zotero 插件