局部用噻吗洛尔治疗遗传性出血性毛细血管扩张症鼻出血 - Suppr

Topical timolol for the treatment of epistaxis in hereditary hemorrhagic telangiectasia.

作者信息

Olitsky Scott E

机构信息

University of Missouri–Kansas City School of Medicine, Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA.

出版信息

Am J Otolaryngol. 2012 May-Jun;33(3):375-6. doi: 10.1016/j.amjoto.2011.10.011. Epub 2011 Nov 12.

DOI:10.1016/j.amjoto.2011.10.011

PMID:22079094

Abstract

摘要

相似文献

Topical timolol for the treatment of epistaxis in hereditary hemorrhagic telangiectasia.局部用噻吗洛尔治疗遗传性出血性毛细血管扩张症鼻出血

Am J Otolaryngol. 2012 May-Jun;33(3):375-6. doi: 10.1016/j.amjoto.2011.10.011. Epub 2011 Nov 12.

Efficacy of TIMOLOL nasal spray as a treatment for epistaxis in hereditary hemorrhagic telangiectasia. A double-blind, randomized, placebo-controlled trial.噻吗洛尔鼻喷剂治疗遗传性出血性毛细血管扩张症鼻出血的疗效。一项双盲、随机、安慰剂对照试验。

Sci Rep. 2019 Aug 19;9(1):11986. doi: 10.1038/s41598-019-48502-9.

Efficacy of Timolol in a Novel Intranasal Thermosensitive Gel for Hereditary Hemorrhagic Telangiectasia-Associated Epistaxis: A Randomized Clinical Trial.Timolol 在一种新型鼻腔热敏凝胶治疗遗传性出血性毛细血管扩张症相关鼻出血中的疗效：一项随机临床试验。

JAMA Otolaryngol Head Neck Surg. 2020 Nov 1;146(11):1006-1014. doi: 10.1001/jamaoto.2020.3025.

Topical application of timolol decreases the severity and frequency of epistaxis in patients who have previously undergone nasal dermoplasty for hereditary hemorrhagic telangiectasia.对于先前因遗传性出血性毛细血管扩张症接受过鼻部皮肤成形术的患者，局部应用噻吗洛尔可降低鼻出血的严重程度和发生频率。

Auris Nasus Larynx. 2016 Aug;43(4):429-32. doi: 10.1016/j.anl.2015.12.001. Epub 2015 Dec 29.

Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.局部用噻吗洛尔治疗遗传性出血性毛细血管扩张症伴心动过缓的鼻出血： CYP2D6代谢变异体研究

BMJ Case Rep. 2014 Feb 11;2014:bcr2013203056. doi: 10.1136/bcr-2013-203056.

[Hereditary hemorrhagic telangiectasia (Osler-Rendu disease)].

Sov Med. 1990(12):111-2.

TIMolol nasal spray as a treatment for epistaxis in hereditary hemorrhagic telangiectasia (HHT) - Study protocol of the prospective, randomized, double-blind, controlled cross-over TIM-HHT trial.TIMolol 鼻喷剂治疗遗传性出血性毛细血管扩张症（HHT）所致鼻出血 - TIM-HHT 前瞻性、随机、双盲、对照交叉试验研究方案。

Clin Hemorheol Microcirc. 2022;80(3):307-315. doi: 10.3233/CH-211253.

Efficacy and safety of propranolol for epistaxis in hereditary haemorrhagic telangiectasia: retrospective, then prospective study, in a total of 21 patients.普萘洛尔治疗遗传性出血性毛细血管扩张症鼻出血的疗效和安全性：一项对21例患者进行的回顾性研究，随后进行前瞻性研究。

Clin Otolaryngol. 2017 Aug;42(4):911-917. doi: 10.1111/coa.12821. Epub 2017 Jan 20.

Efficacy of unusually high doses of tranexamic acid for the treatment of epistaxis in hereditary hemorrhagic telangiectasia.超大量氨甲环酸治疗遗传性出血性毛细血管扩张症鼻出血的疗效

N Engl J Med. 2001 Sep 20;345(12):926. doi: 10.1056/NEJM200109203451216.

Hereditary hemorrhagic telangiectasia/avastin.遗传性出血性毛细血管扩张症/阿瓦斯汀。

Laryngoscope. 2010 Feb;120(2):432-5. doi: 10.1002/lary.20757.

引用本文的文献

Surgical Management of Moderate to Severe Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Meta-Analysis.遗传性出血性毛细血管扩张症中重度鼻出血的外科治疗：系统评价与Meta分析

Am J Rhinol Allergy. 2025 Mar;39(2):159-168. doi: 10.1177/19458924241308952. Epub 2024 Dec 29.

TIMolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (TIM-HHT)-A Prospective, Randomized, Double-Blind, Controlled, Cross-Over Trial.噻吗洛尔鼻腔喷雾剂治疗遗传性出血性毛细血管扩张症鼻出血（TIM-HHT）——一项前瞻性、随机、双盲、对照、交叉试验

Pharmaceutics. 2022 Oct 29;14(11):2335. doi: 10.3390/pharmaceutics14112335.

The Role of Propranolol as a Repurposed Drug in Rare Vascular Diseases.普萘洛尔在罕见血管疾病中的再利用药物作用。

Int J Mol Sci. 2022 Apr 11;23(8):4217. doi: 10.3390/ijms23084217.

Topical Propranolol Improves Epistaxis Control in Hereditary Hemorrhagic Telangiectasia (HHT): A Randomized Double-Blind Placebo-Controlled Trial.外用普萘洛尔改善遗传性出血性毛细血管扩张症（HHT）的鼻出血控制：一项随机双盲安慰剂对照试验。

J Clin Med. 2020 Sep 28;9(10):3130. doi: 10.3390/jcm9103130.

Review of Pharmacological Strategies with Repurposed Drugs for Hereditary Hemorrhagic Telangiectasia Related Bleeding.用于遗传性出血性毛细血管扩张症相关出血的药物再利用药理学策略综述

J Clin Med. 2020 Jun 6;9(6):1766. doi: 10.3390/jcm9061766.

Sci Rep. 2019 Aug 19;9(1):11986. doi: 10.1038/s41598-019-48502-9.

Topical propranolol improves epistaxis in patients with hereditary hemorrhagic telangiectasia - a preliminary report.局部应用普萘洛尔可改善遗传性出血性毛细血管扩张症患者的鼻出血 - 初步报告。

J Otolaryngol Head Neck Surg. 2017 Oct 4;46(1):58. doi: 10.1186/s40463-017-0235-x.

Epistaxis in hereditary hemorrhagic telangiectasia: an evidence based review of surgical management.遗传性出血性毛细血管扩张症的鼻出血：基于证据的手术治疗综述

J Otolaryngol Head Neck Surg. 2016 Jan 12;45:3. doi: 10.1186/s40463-016-0116-8.

A comparative study of propranolol versus silver nitrate cautery in the treatment of recurrent primary epistaxis in children.普萘洛尔与硝酸银烧灼术治疗儿童复发性原发性鼻出血的对比研究

Adolesc Health Med Ther. 2015 Sep 30;6:165-70. doi: 10.2147/AHMT.S84806. eCollection 2015.

Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia.遗传性出血性毛细血管扩张症的抗血管生成治疗策略。

Front Genet. 2015 Feb 11;6:35. doi: 10.3389/fgene.2015.00035. eCollection 2015.

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Topical timolol for the treatment of epistaxis in hereditary hemorrhagic telangiectasia.

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