Yang Frank F, McPherson Bradley, Shu Huang, Xiao Yuhan
Center for Communication Disorders, The University of Hong Kong, Hong Kong, China.
Int J Pediatr Otorhinolaryngol. 2012 Jan;76(1):82-9. doi: 10.1016/j.ijporl.2011.10.005. Epub 2011 Nov 12.
Peripheral hearing loss has been commonly reported in children with non-syndromic cleft lip and/or palate (NSCLP) but few studies have provided information about central auditory nervous system (CANS) functioning for this group. The main objective of this study was to explore CANS functioning in infants with NSCLP through analysis of auditory evoked potentials (AEPs).
AEPs including auditory brainstem response (ABR), middle latency response (MLR), and mismatch negativity (MMN) recordings were conducted in 34 infants of Chinese ethnicity with NSCLP and an equivalent number of normal controls.
There was no significant difference in ABR (all measurements, including wave I, III, V latencies, I-V inter-wave latency, and wave V amplitude), or MLR (recordable components, Na, Pa latencies, and Na-Pa amplitude) findings between the two groups. However, infants with NSCLP had a significantly smaller MMN response than their normal controls, using MMN strength as the measurement.
Significant abnormal auditory evoked potential findings at the cortical level suggest that infants with NSCLP may be at risk of central auditory discrimination dysfunction. Further effort is needed to determine auditory processing abilities in infants with NSCLP.
外周性听力损失在非综合征性唇腭裂（NSCLP）患儿中较为常见，但很少有研究提供该群体中枢听觉神经系统（CANS）功能的相关信息。本研究的主要目的是通过分析听觉诱发电位（AEP）来探索NSCLP婴儿的CANS功能。
对34名中国汉族NSCLP婴儿和数量相当的正常对照组婴儿进行了包括听觉脑干反应（ABR）、中潜伏期反应（MLR）和失配负波（MMN）记录的AEP检测。
两组之间的ABR（所有测量指标，包括波I、III、V潜伏期、I-V波间期和波V波幅）或MLR（可记录成分、Na、Pa潜伏期和Na-Pa波幅）结果无显著差异。然而，以MMN强度为测量指标时，NSCLP婴儿的MMN反应明显小于正常对照组。
皮层水平显著异常的听觉诱发电位结果表明，NSCLP婴儿可能存在中枢听觉辨别功能障碍的风险。需要进一步努力确定NSCLP婴儿的听觉处理能力。
