Goussetis Evgenios, Varela Ioanna, Tsirigotis Panagiotis
Stem Cell Transplant Unit, Aghia Sophia Children's Hospital, Athens, Greece.
Transfus Apher Sci. 2012 Apr;46(2):203-9. doi: 10.1016/j.transci.2011.10.017. Epub 2011 Nov 13.
Extracorporeal photopheresis (ECP) has been used for treatment of steroid-refractory graft versus host disease (GVHD) with encouraging results. Although its exact mechanism of action is not fully understood, photoapheresed cells seem to induce a selective immune response directed against alloreactive T cell populations without causing generalized immunosuppression. Current pediatric experience with ECP for GVHD is available in the form of a few retrospective small studies concerning children with steroid refractory GVHD. Reviewing these data we conclude that ECP is a safe procedure, well tolerated even in low-weight pediatric patients, which warrants further evaluation in well-designed, prospective, controlled studies.
体外光化学疗法（ECP）已用于治疗类固醇难治性移植物抗宿主病（GVHD），效果令人鼓舞。尽管其确切作用机制尚未完全明确，但经光化学处理的细胞似乎能诱导针对同种异体反应性T细胞群体的选择性免疫反应，而不会导致全身免疫抑制。目前关于儿童GVHD的ECP治疗经验来自一些针对类固醇难治性GVHD儿童的回顾性小型研究。通过回顾这些数据，我们得出结论，ECP是一种安全的治疗方法，即使在低体重儿科患者中也能很好耐受，值得在设计良好的前瞻性对照研究中进一步评估。
