肾小球滤过率预测方程在肾移植中的准确性：Architect c8000 上新的胶乳增强散射比浊法测定胱抑素 C 的验证。
Accuracy of GFR predictive equations in renal transplantation: validation of a new turbidimetric cystatin C assay on Architect c8000.
机构信息
Department of Biochemistry, University of Montpellier 1, Montpellier, France.
出版信息
Clin Biochem. 2012 Jan;45(1-2):151-3. doi: 10.1016/j.clinbiochem.2011.10.018. Epub 2011 Nov 6.
OBJECTIVES
To evaluate the Sentinel-PETIA cystatin C on Architect c8000 analyzer.
DESIGN AND METHODS
We assessed analytical performances and clinical relevance by comparison with a reference isotopic method in kidney transplant recipients.
RESULTS
This assay exhibited reliable precision and was close to the non standardized Siemens-PENIA method. All tested equations allowed reliable assessment of GFR.
CONCLUSIONS
Cystatin C improved GFR determination at the critical level of 60 mL/min/1.73 m². New formulas might be necessary after IFCC standardization.
目的
评估 Architect c8000 分析仪上的 Sentinel-PETIA 胱抑素 C。
设计和方法
我们通过与肾移植受者的参考同位素方法进行比较，评估了分析性能和临床相关性。
结果
该测定法具有可靠的精密度，且接近非标准化的西门子-PENIA 方法。所有测试的方程都允许可靠地评估 GFR。
结论
胱抑素 C 在 60 mL/min/1.73 m² 的关键水平提高了 GFR 测定的准确性。在 IFCC 标准化后，可能需要新的公式。
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