阿尔茨海默病进程中的情景记忆。
Episodic memory on the path to Alzheimer's disease.
机构信息
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Curr Opin Neurobiol. 2011 Dec;21(6):929-34. doi: 10.1016/j.conb.2011.10.021. Epub 2011 Nov 11.
Abstract
This review is focused on specific circuits of the medial temporal lobe that have become better understood in recent years for their computational properties contributing to episodic memory and to memory impairment associated with aging and other risk for AD. The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that rapidly encodes representations that are distinct from prior memories. Frank neuron loss in the entorhinal cortex is specific for AD, and related structural and functional changes across the network comprised of the entorhinal cortex and the dentate/CA3 regions hold promise for predicting progression on the path to AD.
摘要
这篇综述重点介绍了内侧颞叶的特定回路，近年来，这些回路的计算特性在情景记忆方面以及与衰老和 AD 风险等相关的记忆障碍方面得到了更好的理解。内嗅皮层的 II 层神经元及其在海马齿状回和 CA3 区的靶标构成了一个系统，该系统可以快速编码与先前记忆不同的表示。内嗅皮层的 Frank 神经元丢失是 AD 的特异性，而包含内嗅皮层和齿状回/CA3 区域的网络的相关结构和功能变化有望预测 AD 进程。
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