Mishra Baijayanti, Rockey Smitha Mary, Gupta Soham, Srinivasa Hiresave, Muralidharan Sethumadhavan
Department of Microbiology, St John's Medical College, Bangalore - 560034, India.
Trop Doct. 2012 Jan;42(1):35-7. doi: 10.1258/td.2011.110247. Epub 2011 Nov 11.
The emergence of multi-drug-resistant (MDR) strains has been a major obstacle in the tuberculosis (TB) control programme. In the present study we looked into the prevalence of MDR-TB in an urban tertiary care hospital in South India over four years (2007-2010). During this period, 641 clinical specimens (317 respiratory specimens and 324 non-respiratory specimens) were received for mycobacteriological culture and drug susceptibility testing for first-line drugs, using the BACTEC 460 TB system. Mycobacterium tuberculosis (MTB) was isolated in 34.8% (n = 223) specimens. Of the total 223 MTB isolates 83 (37.2%) were MDR. Forty-two percent of the pulmonary MTB isolates (n = 72) and 20.4% of the extra-pulmonary isolates (n = 10) were MDR. Although we observed a high percentage of drug resistance, the prevalence of MDR was not observed to vary significantly within the four years which suggested good management.
多重耐药（MDR）菌株的出现一直是结核病（TB）控制计划中的主要障碍。在本研究中，我们调查了印度南部一家城市三级护理医院在四年（2007 - 2010年）期间耐多药结核病的流行情况。在此期间，共接收了641份临床标本（317份呼吸道标本和324份非呼吸道标本），使用BACTEC 460 TB系统进行分枝杆菌培养和一线药物的药敏试验。结核分枝杆菌（MTB）在34.8%（n = 223）的标本中被分离出来。在总共223株MTB分离株中，83株（37.2%）为耐多药菌株。肺部MTB分离株中有42%（n = 72）为耐多药菌株，肺外分离株中有20.4%（n = 10）为耐多药菌株。尽管我们观察到耐药率很高，但在这四年中耐多药的流行率并未观察到显著变化，这表明管理良好。
