建立具有(16;20)染色体易位的人T急性淋巴细胞白血病细胞系。
Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation.
作者信息
Ben-Bassat H, Shlomai Z, Kohn G, Prokocimer M
机构信息
Laboratory of Experimental Surgery, Hadassah University Hospital, Jerusalem, Israel.
出版信息
Cancer Genet Cytogenet. 1990 Oct 15;49(2):241-8. doi: 10.1016/0165-4608(90)90148-4.
A new T-cell line, Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5 +/-, OKT6-, TdT-, and HLA-DR-, indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X,5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.
一种新的T细胞系Loucy是从一名T细胞急性淋巴细胞白血病（T-ALL）患者的外周血中建立的。该细胞系的表面标志物分析结果为OKT3+、OKT4+、THB4+、J5 +/ -、OKT6-、TdT-和HLA-DR-，表明处于T细胞谱系的IV期。核型分析显示为45,X,5q-,t(16;20)(p12;q13)。16号和20号染色体之间的易位此前在急性淋巴细胞白血病中尚未被检测到。该细胞系可能在评估t(16;20)在T-ALL病因学中的作用方面具有价值。
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